Directing Autoimmunity to Nucleoprotein Particles
نویسندگان
چکیده
منابع مشابه
Directing Autoimmunity to Nucleoprotein Particles
Over half a million people in the United States have sys-temic lupus. Most are women in their childbearing years. They usually have arthritis and scarring rashes, and about half have kidney involvement that may progress to renal failure. With time, there is an increasing likelihood that the brain will be involved, often resulting in loss of cognitive ability, seizures, and psychosis. Although t...
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Much progress has recently been made in the study of the ribonucleoprotein particles associated with the microsomal fraction of cell homogenates. The shape and size of these particles as well as their distribution and organization in animal tissues have been studied with the electron microscope (1-4). They appear as round particles with diameters of 100 to 300 A in OsO4-fixed preparations of bo...
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Ultracentrifugal analysis of an extract of pea epicotyls, previously freed of debris and larger particles by centrifugation at 40,000 g for 10 minutes, has revealed the presence of a major component which possesses a sedimentation coefficient of 74 S. This component constitutes about 25 per cent of the TCA-precipitable material in the clarified epicotyl extract and is estimated to make up 1 to ...
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Vault is the largest nonicosahedral cytosolic nucleoprotein particle ever described. The widespread presence and evolutionary conservation of vaults suggest important biologic roles, although their functions have not been fully elucidated. X-ray structure of vault from rat liver was determined at 3.5 Å resolution. It exhibits an ovoid shape with a size of 40 × 40 × 67 nm(3). The cage structure ...
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The submicroscopic nucleoprotein particles of mammalian cytoplasm have been extracted in 0.88 M sucrose, concentrated by high-speed centrifugation, and examined in the analytical ultracentrifuge (10-12). The patterns show large, rapidly spreading boundaries, which have sedi mentation rates of about 130 S and are accom panied by turbidity (12). These boundaries cor respond to the microsomes, par...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2003
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20030130